SNV-FEAST: microbial source tracking with single nucleotide variants

SNV-FEAST: microbial source tracking with single nucleotide variants

Blog Article

Abstract Elucidating the sources of a microbiome can provide insight into the ecological dynamics responsible for the formation of these mqr93ll/a communities.Source tracking approaches to date leverage species abundance information; however, single nucleotide variants (SNVs) may be more informative because of their high specificity to certain sources.To overcome the computational burden of hiboost 4k smart link utilizing all SNVs for a given sample, we introduce a novel method to identify signature SNVs for source tracking.

Signature SNVs used as input into a previously designed source tracking algorithm, FEAST, can more accurately estimate contributions than species and provide novel insights, demonstrated in three case studies.